Symbol
Name
ID

Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Abnormal brain morphology	Ataxia	Delayed speech and language development	Intellectual disability	Developmental regression	Global developmental delay	Specific learning disability	Seizure
Disease(s) Associated with FBXW7
developmental delay, hypotonia, and impaired language

Mouse Phenotypes

nervous system phenotype

abnormal brain vasculature morphology

intracranial hemorrhage

abnormal neuron differentiation

abnormal neural tube closure

open neural tube

abnormal brain development

abnormal cortical intermediate zone morphology

abnormal cortical plate morphology

abnormal cerebellum development

abnormal cerebellar foliation

abnormal tectum morphology

thalamus hypoplasia

abnormal cerebral cortex morphology

abnormal Purkinje cell morphology

decreased Purkinje cell number

decreased Purkinje cell size

abnormal cerebellum fissure morphology

cerebellum vermis hypoplasia

small cerebellum

abnormal embryonic/fetal subventricular zone morphology

decreased neuronal precursor cell number

Availability

Mouse Genotype

Fbxw7^tm1Kin/Fbxw7^tm1Kin

Fbxw7^tm1Sje/Fbxw7^tm1Sje

Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe
Tg(Nes-cre)1Kln/0 (conditional)

Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe
Tg(En2-cre)22Alj/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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